Projects – Renacer Brain Met

RENACER has become a national and international reference for researchers and clinicians interested in brain metastases and a repository for a unique worldwide cohort of this valuable material.

It is therefore expected that the establishment of this Network will act as a critical mass for the organisation of joint research projects, which will enhance the reach of the network and its results, thus contributing to improve scientific knowledge about the disease, while seeking alternative approaches for the development of better diagnostics and treatments, to benefit the patients.

Objectives

Here we include some projects for the fulfilment of RENACER’s objectives:

PerMEDperBRAIN, Establishment of a precision medicine pipeline to personalize the treatment of brain metastasis

Project reference: HR23-00051. CaixaResearch Health 2023 (01/09/2023 – 31/08/2026).

Objective: to develop a genomically-guided precision medicine line for the treatment of brain metastases not conditioned or limited by the conditions of the primary tumour.

RENACER, the National Network on Brain Metastases, as a strategy to challenge lethality, therapeutic resistance and the impact on quality of life associated with brain metastases.

Project reference: PRYCO234528VALI. Proyectos Coordinados AECC 2023. Asociación Española Contra el Cáncer (15/10/2023 – 14/10/2028).

Objective: development of a novel strategy and framework under the umbrella of the RENACER network, to challenge the pillars underlying the poor prognosis of brain metastases, through a more efficient approach to reach specific clinically-relevant goals applicable to cancer patients.

RISEBrain, reverting immune suppression to elicit brain metastasis control

Project reference: TRANSCAN2021-203. ERA-NET TRANSCAN-3. 1. (12/2022-12/2025).

Objective: decipher the cellular landscape and molecular determinants that impose local immune suppression and modulate sensitivity to immunotherapeutic strategies in brain metastasis.

ALTER-brain, metastasis-associated altered molecular patterns in the brain (ALTER-brain)

Project reference: 864759. ERC Consolidator Grant. (07/2020-07/2025).

Objective: dissect the biology of emerging molecular patterns during reprogramming of metastasis-associated microenvironment in the brain and their functional consequences to prevent and treat brain metastasis.

National Brain Metastasis Network: Implementation, Development and Coordination

Project reference: CIVP19S8163; M.V./ CIVP20A6613; E.O. Ramón Areces Foundation. (01/04/2021-15/05/2024).

Objective: development and implementation of a collaborative framework for the identification, collection, and characterisation of brain metastasis samples, with the aim of promoting research in this field, and to generate a repository of this valuable material.