The group studies why and how cells from different cancer types (breast cancer, lung cancer and melanoma) are able to access the brain, survive and colonise this vital organ. They dissect the biology of these processes in vivo using experimental models in order to challenge the current status of this unmet clinical need. The goal is to understand the biology of brain metastases and their impact on organ function using experimental mouse models as well as patient-derived material to translate this knowledge into more and better opportunities to prevent and to treat secondary brain tumours.